apalutamide will decrease the level or impact of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Stay clear of or Use Alternate Drug. Coadministration of apalutamide, a strong CYP2C19 inducer, with medication that are CYP2C19 substrates may end up in reduce exposure to those drugs.fluvoxamine will enhance the degree or outcome of diazepam